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Concomitant administration with cardiac glycosides may potentiate/increase glycoside effect.
Concomitant administration with diuretics may potentiate/increase potassium-depleting effect.
The hypoglycaemic effect on antidiabetic agents and the anticoagulant effect of coumarin derivatives may be reduced by glucocorticoids.
Concomitant administration with Rifampicin, Phenytoin or Barbiturates may reduce corticosteroid effect.
Concomitant administration with Acetosal may potentiate/increase the clearance of chronic high-dose Acetosal.
Convulsions have been reported with concurrent use of Methylprednisolone and Cyclosporin.
Concomitant administration with Ketoconazole and Troleandomycin may inhibit the metabolism of Methylprednisolone and thus, decrease its clearance.
